Peroxisomal fatty acid oxidation capacity is more resistant to ischaemic and reperfusion injury than mitochondrial fatty acid oxidation capacity in feline hearts

• Published in: Acta physiologica Scandinavica 1996-06, Vol.157 (2), p.133-145
• Main Authors: BRUNVAND, H., FRØYLAND, L., WESTBY, J., HEXEBERG, E., BERGE, R. K., GRONG, K.
• Format: Article
• Language: English
• Subjects: Adenine Nucleotides - metabolism; Adenosine Triphosphate - metabolism; Animals; Biological and medical sciences; Cardiology. Vascular system; Cats; Coronary Circulation - physiology; Coronary heart disease; Fatty Acids - metabolism; Heart; In Vitro Techniques; Male; Medical sciences; Microbodies - metabolism; Mitochondria, Heart - metabolism; Myocardial Contraction - physiology; myocardial ischaemia and reperfusion; Myocardial Ischemia - metabolism; myocardial metabolism; Myocardial Reperfusion Injury - metabolism; Oxidation-Reduction; regional function
• ISSN: 0001-6772; 1365-201X
• DOI: 10.1046/j.1365-201X.1996.498243000.x

We investigated ischaemic and postischaemic mitochondrial and peroxisomal fatty acid oxidation capacity, ATP levels and regional function in 40 anaesthetized open chest cats subjected to 10 or 40 min of regional myocardial ischaemia with or without 3 h of reperfusion (n=10 in each situation). Following 10 min of ischaemia, the mitochondrial fatty acid oxidation capacity measured in tissue extracts from ischaemic tissue (nmol min‐1 mg protein‐1) was reduced in both subepi‐ and subendocardium, but was normalized in reperfused tissue extracts from both wall layers (0.29±0.03 and 0.30±0.04 vs. 0.57±0.05 and 0.59±0.05, P