Altered Minimal Coronary Resistance to Antegrade Reflow After Chronic Coronary Artery Occlusion in Swine

We examined coronary pressure-flow relations after chronic coronary artery occlusion induced by placement of an ameroid occluder on the left circumflex coronary artery in swine. An acute open-chest procedure was performed in nine pigs 27 ± 2 days (mean ± SEM) after surgical placement of the ameroid...

Full description

Saved in:
Bibliographic Details
Published in:Circulation research 1988-08, Vol.63 (2), p.330-339
Main Authors: Roth, D M, White, F C, Bloor, C M
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cardiology - instrumentation
Cardiology. Vascular system
Chronic Disease
Coronary Circulation
Coronary Disease - physiopathology
Coronary heart disease
Dogs
Heart
Hemodynamics
Medical sciences
Swine
Vascular Resistance
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We examined coronary pressure-flow relations after chronic coronary artery occlusion induced by placement of an ameroid occluder on the left circumflex coronary artery in swine. An acute open-chest procedure was performed in nine pigs 27 ± 2 days (mean ± SEM) after surgical placement of the ameroid occluder, and in eight nonoperated control pigs. Coronary vascular resistances were measured during maximal coronary vasodilation with adenosine. Minimal coronary resistance was assessed before and after cannulation and extracorporeal perfusion of the left circumflex coronary artery distal to the site of the ameroid occluder in pigs from the ameroid group and in a similar site in control pigs. Minimal coronary resistance to antegrade reflow in the left circumflex region was decreased significantly in ameroid pigs compared with control pigs (0.06 ± 0.01 vs. 0.26 ± 0.03 mm Hg ± min ± 100 g/ml, p
ISSN:0009-7330
1524-4571
DOI:10.1161/01.RES.63.2.330