Ultrastructural study of an apatite layer formed by a biomimetic process and its bonding to bone

A dense and uniform apatite layer about 20μm thick was formed on a poly(ether sulphone) (PESF) substrate treated with glow discharge in O 2 gas by a biomimetic process. The apatite-polymer composite obtained was implanted into a rabbit tibia and the structure of the PESF-apatite-bone interface was o...

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Bibliographic Details
Published in:Biomaterials 1996, Vol.17 (1), p.47-51
Main Authors: Tanahashi, Masami, Kokubo, Tadashi, Nakamura, Takashi, Katsura, Yoshiaki, Nagano, Masahisa
Format: Article
Language:English
Subjects:
Animals
Apatites - chemistry
Apatites - metabolism
Binding Sites
Biological and medical sciences
biomimetic process
Bone-like apatite
Crystallization
implantation
Male
Medical sciences
Microscopy, Electron
Microscopy, Electron, Scanning
Oxygen
Partial Pressure
Polymers - metabolism
Prostheses and Implants
Rabbits
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Sulfones - metabolism
Technology. Biomaterials. Equipments. Material. Instrumentation
TEM
Tibia - metabolism
Tibia - ultrastructure
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Summary:A dense and uniform apatite layer about 20μm thick was formed on a poly(ether sulphone) (PESF) substrate treated with glow discharge in O 2 gas by a biomimetic process. The apatite-polymer composite obtained was implanted into a rabbit tibia and the structure of the PESF-apatite-bone interface was observed under a scanning and a transmission electron microscope 8 weeks after implantation. The apatite layer formed by the biomimetic process was confirmed to consist of small crystals of apatite with a structure similar to that of apatite in bone. The apatite layer remained on the substrate in the body, and bonded to the apatite in the bone directly. This type of apatite-organic polymer composite expected to be useful as bone-repairing material.
ISSN:0142-9612
1878-5905
DOI:10.1016/0142-9612(96)80754-X