Which intravenous induction agent for day surgery? a comparison of propofol, thiopentone, methohexitone and etomidate

Eighty day patients for the vaginal termination of pregnancy were randomly allocated to receive thiopentone, propofol, methohexitone or etomidate as intravenous induction agents. The same anaesthetist administered the anaesthesia and all the observers were blind to the agents used. The results show...

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Bibliographic Details
Published in:Anaesthesia 1988-05, Vol.43 (5), p.365-368
Main Authors: HEATH, P. J, KENNEDY, D. J, OGG, T. W, DUNLING, C, GILKS, W. R
Format: Article
Language:English
Subjects:
Abortion, Induced
Adolescent
Adult
Ambulatory Surgical Procedures
Anesthesia Recovery Period
Anesthesia, Intravenous
Anesthesia, Obstetrical
Anesthetics - pharmacology
Anesthetics. Neuromuscular blocking agents
Biological and medical sciences
Drug Evaluation
Etomidate - pharmacology
Female
Humans
Medical sciences
Methohexital - pharmacology
Middle Aged
Neuropharmacology
Pharmacology. Drug treatments
Phenols - pharmacology
Pregnancy
Propofol
Random Allocation
Thiopental - pharmacology
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Summary:Eighty day patients for the vaginal termination of pregnancy were randomly allocated to receive thiopentone, propofol, methohexitone or etomidate as intravenous induction agents. The same anaesthetist administered the anaesthesia and all the observers were blind to the agents used. The results show that thiopentone and propofol produced the least sequelae at induction and in recovery. Furthermore, both agents produced a high quality of induction and recovery. All patients were discharged home 2 hours postoperatively and there was no obvious delay in recovery. This study has altered clinical practice in our Day Surgery Unit.
ISSN:0003-2409
1365-2044
DOI:10.1111/j.1365-2044.1988.tb09014.x