p-SPA, a peripheral adenosine A1 analogue, reduces sleep apneas in rats

The actions of N6-p-sulfophenyladenosine (p-SPA), a novel peripherally selective adenosine A1 agonist, were assessed on spontaneous and postsigh central sleep apneas in freely moving, unanesthetized rats by simultaneously monitoring sleep and respiration. Intraperitoneal administration of 0.1, 0.3,...

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Published in:Pharmacology, biochemistry and behavior biochemistry and behavior, 1996-02, Vol.53 (2), p.341-345
Main Authors: MONTI, D, CARLEY, D. W, RADULOVACKI, M
Format: Article
Language:English
Subjects:
Adenosine - analogs & derivatives
Adenosine - pharmacology
Adenosine - therapeutic use
Animals
Biological and medical sciences
Medical sciences
Peripheral Nervous System - drug effects
Peripheral Nervous System - physiopathology
Pharmacology. Drug treatments
Polysomnography - drug effects
Purinergic P1 Receptor Agonists
Rats
Rats, Sprague-Dawley
Respiratory Mechanics - drug effects
Respiratory system
Sleep Apnea Syndromes - drug therapy
Sleep Apnea Syndromes - physiopathology
Time Factors
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Summary:The actions of N6-p-sulfophenyladenosine (p-SPA), a novel peripherally selective adenosine A1 agonist, were assessed on spontaneous and postsigh central sleep apneas in freely moving, unanesthetized rats by simultaneously monitoring sleep and respiration. Intraperitoneal administration of 0.1, 0.3, and 1.0 mg/kg of the drug significantly decreased postsigh and spontaneous sleep apnea index (AI). This effect persisted throughout the 6-h recording period. Doses of 0.1 and 0.3 mg/kg did not affect sleep efficiency, whereas 1.0 mg/kg of p-SPA reduced it to 60% of baseline value.
ISSN:0091-3057
1873-5177
DOI:10.1016/0091-3057(95)02032-2