Calcium-binding protein in human duodenal biopsies

Intestinal calcium-binding protein (CaBP) (molecular weight 10,000) was measured by a specific enzyme-linked immunoadsorbent assay in duodenal biopsies of 94 patients (aged 20-89 years). The patients were examined for complaints of upper abdominal dyspepsia, but no significant pathology was found by...

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Bibliographic Details
Published in:Calcified tissue international 1988-04, Vol.42 (4), p.205-209
Main Authors: STAUN, M, BOESBY, S, DAUGAARD, H, JARNUM, S
Format: Article
Language:English
Subjects:
Adult
Aged
Aging
Alkaline Phosphatase - analysis
Analytical, structural and metabolic biochemistry
Binding and carrier proteins
Biological and medical sciences
Biopsy
Calcitriol - blood
Calcium - blood
Calcium - metabolism
Calcium-Binding Proteins - analysis
Duodenum - analysis
Duodenum - enzymology
Duodenum - pathology
Fundamental and applied biological sciences. Psychology
Humans
Middle Aged
Parathyroid Hormone - blood
Phosphates - blood
Proteins
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Summary:Intestinal calcium-binding protein (CaBP) (molecular weight 10,000) was measured by a specific enzyme-linked immunoadsorbent assay in duodenal biopsies of 94 patients (aged 20-89 years). The patients were examined for complaints of upper abdominal dyspepsia, but no significant pathology was found by gastroduodenoscopy. The median amount of CaBP in duodenal biopsies was 6.0 micrograms/mg of cytosolic protein with a coefficient of variation of 0.6. No change in the amount of CaBP per mg of cytosolic protein was observed with age. A significant correlation (P less than 0.001) was found between the concentration of CaBP and s-1,25-dihydroxyvitamin D (1,25(OH)2D). The amount of CaBP per mg of cytosolic protein did not correlate with immunoreactive parathyroid hormone in serum, and no relation between CaBP and the specific activity of alkaline phosphatase of the mucosal biopsies was found. The results of the present study show a wide variation in the amount of the 10 kDa CaBP in duodenal biopsies of humans and no change with age. Further, a correlation between s-1,25(OH)2D and CaBP was found.
ISSN:0171-967X
1432-0827
DOI:10.1007/BF02553745