Autoradiographic evidence of μ-opioid receptors down-regulation after prenatal stress in offspring rat brain

In order to visualize neuroanatomical alterations in specific brain regions, light microscopy autoradiography was carried out on offspring (postnatal day 10) from female rats stressed in different periods of gestation and controls. Group 1 was subjected to restraint stress from day 2 to 6; group 2,...

Full description

Saved in:
Bibliographic Details
Published in:Brain research. Developmental brain research 1996-06, Vol.94 (1), p.14-21
Main Authors: Sanchez, M.Dolores, Milanés, M.Victoria, Pazos, Angel, Diaz, Alvaro, Laorden, M.L.
Format: Article
Language:English
Subjects:
Analgesics - pharmacology
Animals
Autoradiography
beta-Endorphin - metabolism
Brain Chemistry - physiology
Down-Regulation - physiology
Downregulation
Enkephalin, Ala-MePhe-Gly
Enkephalins - pharmacology
Female
Male
Offspring
Pregnancy
Prenatal Exposure Delayed Effects
Prenatal stress
Rats
Rats, Sprague-Dawley
Receptors, Opioid, mu - agonists
Receptors, Opioid, mu - metabolism
Receptors, Opioid, mu - physiology
Stress, Physiological - physiopathology
Tritium
μ-Opioid receptor
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In order to visualize neuroanatomical alterations in specific brain regions, light microscopy autoradiography was carried out on offspring (postnatal day 10) from female rats stressed in different periods of gestation and controls. Group 1 was subjected to restraint stress from day 2 to 6; group 2, from day 7 to 11; group 3, from day 12 to 16; group 4, from day 2 to 16. Group 2 showed pronounce decreases in μ-opioid receptor density in different brain regions. The decrease in μ-opioid receptor density was less marked in the group 1, 3 and 4. Present data suggest that the prenatal stress induce down-regulation of μ-receptors in different brain regions.
ISSN:0165-3806
DOI:10.1016/0165-3806(96)00032-6