Reduction of autotomy following peripheral neurectomy by a single injection of bupivacaine into the cingulum bundle of rats

Peripheral neurectomy in rats is followed by autotomy of the denervated zone, which is assumed to represent an index of pain or dysesthesia. In the present study, we examined whether a single injection of a local anesthetic (bupivacaine) into the cingulum bundle at the time of nerve section could re...

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Bibliographic Details
Published in:Brain research 1996-06, Vol.723 (1), p.214-217
Main Authors: Magnusson, Jane E., Vaccarino, Anthony L.
Format: Article
Language:English
Subjects:
Anesthetics. Neuromuscular blocking agents
Animals
Autotomy
Biological and medical sciences
Bupivacaine
Bupivacaine - pharmacology
Central sensitization
Cingulum bundle
Gyrus Cinguli - drug effects
Male
Medical sciences
Neurons - physiology
Neuropharmacology
Pain
Pain - physiopathology
Peripheral neurectomy
Pharmacology. Drug treatments
Rats
Time Factors
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Summary:Peripheral neurectomy in rats is followed by autotomy of the denervated zone, which is assumed to represent an index of pain or dysesthesia. In the present study, we examined whether a single injection of a local anesthetic (bupivacaine) into the cingulum bundle at the time of nerve section could reduce autotomy. It was found that a temporary anesthetic blockade of the cingulum at the time of nerve section delayed the onset and reduced the overall degree of autotomy. However, injections given shortly after nerve section had no significant effects. These results demonstrate that temporary blockade of cingulum activity at the time of nerve section reduces autotomy for periods that exceed the duration of the anesthetic block.
ISSN:0006-8993
1872-6240
DOI:10.1016/0006-8993(96)00255-7