EFFECTS OF DEXFENFLURAMINE ON GLUCOSE DRINKING AND GLUCOSE-CONDITIONED FLAVOUR PREFERENCES IN RATS: TASTE VERSUS POST-INGESTIVE CONDITIONING

A comparison was made of the effects of dexfenfluramine (DF, 3–10mgkg −1) on intake of and conditioning with glucose solutions varying in orostimulant properties (taste) and post-ingestive actions (calories), in rats. First, sham-feeding, using gastric-fistulated rats, was performed to assess the or...

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Bibliographic Details
Published in:Pharmacological Research 1996, Vol.33 (1), p.41-46
Main Authors: YILDIZ, O., BOLU, E., DENIZ, G., ŞENÖZ, S., ŞIMŞEK, A., ÖZATA, M., GÜNDOGAN, N., GÜNDOG̃AN, M.A.
Format: Article
Language:English
Subjects:
Animals
conditioning
Conditioning, Classical
consumption
dexfenfluramine
Drinking Behavior - drug effects
Energy Intake
Feeding Behavior - drug effects
Fenfluramine - pharmacology
Flavoring Agents
flavour
Glucose
Male
Rats
Rats, Wistar
Taste - drug effects
Weight Gain - drug effects
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Summary:A comparison was made of the effects of dexfenfluramine (DF, 3–10mgkg −1) on intake of and conditioning with glucose solutions varying in orostimulant properties (taste) and post-ingestive actions (calories), in rats. First, sham-feeding, using gastric-fistulated rats, was performed to assess the orostimulant properties of the solutions. Then, two experiments were done. In the first experiment, we examined the effects of DF, given at doses of 13 and 10mgkg −1, on the intake of two glucose solutions having different orostimulant properties and different caloric values. The solutions were a mix of 1% glucose plus 0.125% saccharin (low caloric, more orostimulant), and 4% glucose (high caloric, less orostimulant). At doses of 10mgkg −1, DF administration markedly reduced intake of both solutions ( P
ISSN:1043-6618
1096-1186
DOI:10.1006/phrs.1996.0007