Beta-blockade antagonism of tyramine-induced rise in blood pressure

The effect beta-adrenoceptor blockade on the pressor response to tyramine has been investigated in 6 healthy volunteers, each submitted to an i.v. tyramine pressor test before and after 7 days of propranolol 40 mg b.d. or indenolol 60 mg o.d. Tyramine was given as i.v. boluses of 1-6 mg, alternating...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1988-01, Vol.34 (3), p.263-266
Main Authors: COLOMBO, F, SEGA, R, MAILLAND, F, RIGO, R, PALVARINI, L, LIBRETTI, A
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - pharmacology
Adult
Antihypertensive agents
Biological and medical sciences
Blood Pressure - drug effects
Cardiovascular system
Humans
Indenes - pharmacology
Male
Medical sciences
Pharmacology. Drug treatments
Propanolamines - pharmacology
Propranolol - pharmacology
Random Allocation
Tyramine - antagonists & inhibitors
Vasodilation - drug effects
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Summary:The effect beta-adrenoceptor blockade on the pressor response to tyramine has been investigated in 6 healthy volunteers, each submitted to an i.v. tyramine pressor test before and after 7 days of propranolol 40 mg b.d. or indenolol 60 mg o.d. Tyramine was given as i.v. boluses of 1-6 mg, alternating with saline, in a randomized, single blind fashion. Prior to treatment tyramine caused a temporary, dose-dependent increase in systolic and diastolic blood pressure, whilst the heart rate remained unaffected. Both propranolol and indenolol reduced the pressor response to tyramine, as shown by a significant increase in ED15, i.e. the dose of tyramine required to increase systolic blood pressure by 15%.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00540953