Evolutionary Conservation of Sequence Elements Controlling Cytoplasmic Polyadenylylation

Cytoplasmic polyadenylylation is an evolutionarily conserved mechanism involved in the translational activation of a set of maternal messenger RNAs (mRNAs) during early development. In this report, we show by interspecies injections that Xenopus and mouse use the same regulatory sequences to control...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1996-08, Vol.93 (17), p.9027-9032
Main Authors: Verrotti, Arturo C., Thompson, Sunnie R., Wreden, Christopher, Strickland, Sidney, Wickens, Marvin
Format: Article
Language:English
Subjects:
Animals
Base Sequence
Biological Evolution
Conserved Sequence
Cyclins
Cytoplasm - metabolism
Developmental biology
Drosophila
Embryos
Fertilization
Freshwater
Frogs
Meiosis
Messenger RNA
Mice
Molecular Sequence Data
Oocytes
RNA
RNA Processing, Post-Transcriptional
RNA, Messenger - biosynthesis
Species Specificity
Untranslated regions
Xenopus
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Summary:Cytoplasmic polyadenylylation is an evolutionarily conserved mechanism involved in the translational activation of a set of maternal messenger RNAs (mRNAs) during early development. In this report, we show by interspecies injections that Xenopus and mouse use the same regulatory sequences to control cytoplasmic poly(A) addition during meiotic maturation. Similarly, Xenopus and Drosophila embryos exploit functionally conserved signals to regulate polyadenylylation during early post-fertilization development. These experiments demonstrate that the sequence elements that govern cytoplasmic polyadenylylation, and hence one form of translational activation, function across species. We infer that the requisite regulatory sequence elements, and likely the trans-acting components with which they interact, have been conserved since the divergence of vertebrates and arthropods.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.93.17.9027