Klebsiella antibodies in ankylosing spondylitis and Proteus antibodies in rheumatoid arthritis

Antibodies to Klebsiella, but not to other bacteria, have been shown to be present in patients with active ankylosing spondylitis (AS) by seven different techniques. Antibodies to Proteus, but not to E. coli or Klebsiella, have been shown to be present in patients with active rheumatoid arthritis (R...

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Bibliographic Details
Published in:British journal of rheumatology 1988, Vol.27 Suppl 2, p.72-85
Main Authors: Ebringer, A, Cox, N L, Abuljadayel, I, Ghuloom, M, Khalafpour, S, Ptaszynska, T, Shodjai-Moradi, F, Wilson, C
Format: Article
Language:English
Subjects:
Animals
Antibodies, Bacterial - analysis
Arthritis, Rheumatoid - immunology
Cross Reactions
Enzyme-Linked Immunosorbent Assay
HLA Antigens - immunology
HLA-B27 Antigen
Humans
Immunologic Techniques
Klebsiella - immunology
Proteus - immunology
Rabbits
Spondylitis, Ankylosing - immunology
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Summary:Antibodies to Klebsiella, but not to other bacteria, have been shown to be present in patients with active ankylosing spondylitis (AS) by seven different techniques. Antibodies to Proteus, but not to E. coli or Klebsiella, have been shown to be present in patients with active rheumatoid arthritis (RA) by three different techniques. It is suggested AS and RA are forms of reactive arthritis, to Klebsiella and Proteus respectively, probably mediated by cross-reactivity to HLA antigens.
ISSN:0263-7103