Infectious Complications of Human T Cell Leukemia/Lymphoma Virus Type I Infection

Infection with human T cell leukemia/lymphoma virus type I (HTLV-I) has been etiologically associated with two diseases: adult T cell leukemia and HTLV-I-associated myelopathy/tropical spastic paraparesis. Increasing evidence suggests that HTLV-I infection may be associated with immunosuppression an...

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Bibliographic Details
Published in:Clinical infectious diseases 1996-07, Vol.23 (1), p.138-145
Main Author: MARSH, B. J
Format: Article
Language:English
Subjects:
Adult
AIDS-Related Opportunistic Infections - complications
AIDS/HIV
Animals
Biological and medical sciences
HIV
HTLV I infections
HTLV-I Infections - complications
HTLV-I Infections - etiology
Human T lymphotropic virus 1
Human viral diseases
Humans
Immune Tolerance
Infections
Infectious diseases
Leprosy
Leprosy - complications
Leprosy - etiology
Leukemia-Lymphoma, Adult T-Cell - etiology
Medical sciences
Mycobacterium tuberculosis
Opportunistic Infections - complications
Paraparesis, Tropical Spastic - etiology
Review Articles
Strongylida Infections - complications
Strongylida Infections - etiology
Strongyloidiasis
T lymphocytes
Tuberculosis
Tuberculosis, Pulmonary - complications
Tuberculosis, Pulmonary - etiology
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viruses
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Description
Summary:Infection with human T cell leukemia/lymphoma virus type I (HTLV-I) has been etiologically associated with two diseases: adult T cell leukemia and HTLV-I-associated myelopathy/tropical spastic paraparesis. Increasing evidence suggests that HTLV-I infection may be associated with immunosuppression and, as a consequence, affect the risk and expression of several other infectious diseases, of which the best studied are strongyloidiasis, tuberculosis, and leprosy. In strongyloidiasis, coinfection with HTLV-I appears to result in a higher rate of chronic carriage, an increased parasite load, and a risk of more severe infection. In tuberculosis, a decrease in delayed-type hypersensitivity to Mycobacterium tuberculosis has been established, but whether this decrease is clinically significant has yet to be determined. In leprosy, an increased risk of disease is suggested, but the published studies are all too poorly controlled to draw definite conclusions.
ISSN:1058-4838
1537-6591
DOI:10.1093/clinids/23.1.138