N-[1-(2-Benzo(tb)thiophenyl)cyclohexyl]piperidine (BTCP) and cocaine induce similar effects on striatal dopamine: a microdialysis study in freely moving rats

N-[1-(2-Benzo( b)thiophenyl)cyclohexyl]piperidine (BTCP) and cocaine inhibit dopamine (DA) uptake but bind to different sites on the transporter. Their dose-dependent effects (i.p. administration) on extracellular DA levels in the rat striatum were measured by in vivo microdialysis. Both drugs dose-...

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Bibliographic Details
Published in:Neuroscience letters 1996-06, Vol.211 (3), p.179-182
Main Authors: Martin-Fardon, Rémi, Arnaud, Martial, Rousseau, Églantine, Kamenka, Jean-Marc, Privat, Alain, Vignon, Jacques
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cocaine
Cocaine - pharmacology
Corpus Striatum - drug effects
Dopamine
Dopamine - metabolism
Dose-Response Relationship, Drug
Freely moving rat
In vivo microdialysis
Male
Medical sciences
Microdialysis
N-[1-(2-Benzo( b)thiophenyl)cyclohexyl]piperidine
Neuropharmacology
Pharmacology. Drug treatments
Piperidines - pharmacology
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rats
Rats, Wistar
Striatum
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Summary:N-[1-(2-Benzo( b)thiophenyl)cyclohexyl]piperidine (BTCP) and cocaine inhibit dopamine (DA) uptake but bind to different sites on the transporter. Their dose-dependent effects (i.p. administration) on extracellular DA levels in the rat striatum were measured by in vivo microdialysis. Both drugs dose-dependently increased DA levels with a maximum effect 60 min post injection. BTCP (20 mg/kg) had a greater peak effect than cocaine (40 mg/kg). For doses inducing similar behavioral effects (cocaine, 20 mg/kg; BTCP, 10 mg/kg) similar DA increases were observed in the striatum and the nucleus accumbens. Although both drugs bind on the DA transporter on different sites and induce different behavioral effects when administered chronically, their acute administration increased striatal DA level in a similar way.
ISSN:0304-3940
1872-7972
DOI:10.1016/0304-3940(96)12744-0