Determination of ibogaine in plasma by gas chromatography-chemical ionization mass spectrometry

Ibogaine is a naturally occurring indole alkaloid that is currently being considered as a treatment medication for drug dependence. Although there have been a variety of investigation regarding the mechanisms of action and pharmacology of ibogaine, relatively little has been reported regarding quant...

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Bibliographic Details
Published in:Journal of Chromatography A 1996-02, Vol.723 (1), p.101-109
Main Authors: Ley, F.Robert, Jeffcoat, A.Robert, Thomas, Brian F.
Format: Article
Language:English
Subjects:
Alkaloids
Carbon Isotopes
Gas Chromatography-Mass Spectrometry - methods
Gas Chromatography-Mass Spectrometry - statistics & numerical data
Hallucinogens - blood
Humans
Ibogaine
Ibogaine - blood
Quality Control
Tritium
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Summary:Ibogaine is a naturally occurring indole alkaloid that is currently being considered as a treatment medication for drug dependence. Although there have been a variety of investigation regarding the mechanisms of action and pharmacology of ibogaine, relatively little has been reported regarding quantitative methods. Because of the paucity of analytical methodologies, studies involving the pharmacokinetics and metabolism of ibogaine have also been limited. A method is described for the determination of ibogaine levels in plasma by gas chromatography-methane chemical ionization mass spectrometry. [ 13C 2H 3]Ibogaine was synthesized and used as an internal standard to control for recovery during sample preparation. The assay requires one ml of plasma and is shown to be a selective and sensitive means of ibogaine quantitation.
ISSN:0021-9673
DOI:10.1016/0021-9673(95)00827-6