Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q

Metabotropic glutamate receptors (GRMs) are neurotransmitter receptors that respond to glutamate stimulations by activating GTP-binding proteins and modulating second-messenger cascades. Eight related GRMs have been identified to date. In this study, we have mapped GRM3 and GRM8 to human chromosome...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 1996-01, Vol.31 (2), p.230-233
Main Authors: SCHERER, S. W, DUVOISIN, R. M, KUHN, R, HENG, H. H. Q, BELLONI, E, TSUI, L.-C
Format: Article
Language:English
Subjects:
Animals
Base Sequence
Biological and medical sciences
Chromosome Mapping
Chromosomes, Human, Pair 7 - genetics
Classical genetics, quantitative genetics, hybrids
DNA - genetics
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Genome, Human
Human
Humans
Molecular Sequence Data
Rats
Receptors, Metabotropic Glutamate - genetics
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Summary:Metabotropic glutamate receptors (GRMs) are neurotransmitter receptors that respond to glutamate stimulations by activating GTP-binding proteins and modulating second-messenger cascades. Eight related GRMs have been identified to date. In this study, we have mapped GRM3 and GRM8 to human chromosome 7q21.1-q21.2 and 7q31.3-q32.1, respectively, using somatic cell hybrid and fluorescence in situ hybridization analysis. A yeast artificial chromosome contig was constructed surrounding the genes, allowing their location to be integrated into the genetic and physical map of chromosome 7.
ISSN:0888-7543
1089-8646
DOI:10.1006/geno.1996.0036