Effects of tumor necrosis factor (TNF) on lipolytic activities of rat heart

Tumor Necrosis Factor (TNF) inhibits lipoprotein lipase activity in cultured myocytes and in the Langendorff rat heart after 3 h perfusion with TNF of glucocorticoid-pretreated rats. TNF acutely stimulates glyc(ogen)olysis and concomitantly endogenous lipolysis. The latter was significantly increase...

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Bibliographic Details
Published in:Molecular and cellular biochemistry 1988-02, Vol.79 (2), p.147-151
Main Authors: Hülsmann, W C, Dubelaar, M L
Format: Article
Language:English
Subjects:
Animals
Cyclic AMP - metabolism
Cyclic GMP - metabolism
Glycerol - metabolism
Glycogen - metabolism
Heart - drug effects
Hydrocortisone - pharmacology
Lactates - metabolism
Lactic Acid
Lipolysis - drug effects
Lipoprotein Lipase - antagonists & inhibitors
Male
Myocardial Contraction - drug effects
Myocardium - cytology
Myocardium - enzymology
Myocardium - metabolism
Rats
Tumor Necrosis Factor-alpha - pharmacology
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Summary:Tumor Necrosis Factor (TNF) inhibits lipoprotein lipase activity in cultured myocytes and in the Langendorff rat heart after 3 h perfusion with TNF of glucocorticoid-pretreated rats. TNF acutely stimulates glyc(ogen)olysis and concomitantly endogenous lipolysis. The latter was significantly increased only when rats had been pretreated with glucocorticoid or fed a trierucate-rich diet. Under these conditions, contractile activity of the Langendorff hearts was acutely increased by TNF. The mechanism of the acute increase of contractile function and the accompanying increased glycolytic and lipolytic activities, by TNF, may be explained by increased cytosolic Ca2+ and cAMP levels.
ISSN:0300-8177
1573-4919
DOI:10.1007/BF02424557