Effect of gonadotropin-releasing hormone on estrogen receptor messenger ribonucleic acid level in perifused pituitary cells

1. We examined the potential effect of GnRH pulses on pituitary estrogen receptor mRNA level. 2. The treatment of perifused pituitary cell aggregates with four hourly pulses of GnRH (10nM/1 min/h) resulted in a marked increase in the steady-state level of ER mRNA (25% vs unstimulated control, n = 3)...

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Bibliographic Details
Published in:Cellular and molecular neurobiology 1996-06, Vol.16 (3), p.397-402
Main Authors: Demay, F, Tiffoche, C, Thieulant, M L
Format: Article
Language:English
Subjects:
Animals
Cells, Cultured
Female
Gonadotropin-Releasing Hormone - pharmacology
Luteinizing Hormone - metabolism
Pituitary Gland, Anterior - cytology
Pituitary Gland, Anterior - drug effects
Pituitary Gland, Anterior - metabolism
Rats
Rats, Wistar
Receptors, Estrogen - biosynthesis
Receptors, Estrogen - genetics
RNA, Messenger - biosynthesis
RNA, Messenger - genetics
Up-Regulation - drug effects
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Summary:1. We examined the potential effect of GnRH pulses on pituitary estrogen receptor mRNA level. 2. The treatment of perifused pituitary cell aggregates with four hourly pulses of GnRH (10nM/1 min/h) resulted in a marked increase in the steady-state level of ER mRNA (25% vs unstimulated control, n = 3). 3. No changes were observed for the LH beta mRNA. Data suggest, for the first time, that a cross-talk between the GnRH and nuclear ER may occur in the gonadotrope cells.
ISSN:0272-4340
1573-6830
DOI:10.1007/BF02088103