Chromosomal assignment of the gene encoding the human 58-kDa inhibitor (PRKRI) of the interferon-induced dsRNA-activated protein kinase to chromosome 13q32

The 58-kDa inhibitor (p58) of the interferon-induced dsRNA-activated protein kinase (PKR) is a cellular protein recruited by the influenza virus to down-regulate the activity of PKR during virus infection. The inhibitor also appears to play a role in the regulation of cellular gene expression in the...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 1996-01, Vol.31 (2), p.238-239
Main Authors: KORTH, M. J, EDELHOFF, S, DISTECHE, C. M, KATZE, M. G
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chromosome Mapping
Chromosomes, Human, Pair 13 - genetics
Classical genetics, quantitative genetics, hybrids
eIF-2 Kinase
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Genome, Human
HeLa Cells
HSP40 Heat-Shock Proteins
Human
Humans
Interferons - pharmacology
Protein-Serine-Threonine Kinases - antagonists & inhibitors
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Summary:The 58-kDa inhibitor (p58) of the interferon-induced dsRNA-activated protein kinase (PKR) is a cellular protein recruited by the influenza virus to down-regulate the activity of PKR during virus infection. The inhibitor also appears to play a role in the regulation of cellular gene expression in the absence of viral infection and has oncogenic properties when overexpressed. Using fluorescence in situ hybridization, we have mapped the p58 gene (PRKRI) to human chromosome 13 band q32. Aberrations in the structure or number of chromosome 13 have been identified in a variety of human cancers, particularly in acute leukemia.
ISSN:0888-7543
1089-8646
DOI:10.1006/geno.1996.0038