Epidemiology of Clostridium difficile Colonization in Newborns: Results Using a Bacteriophage and Bacteriocin Typing System

We used a typing system based on bacteriophage and bacteriocin susceptibility to study the epidemiology of Clostridium difficile colonization of newborn infants. C. difficile was found in the stools of 30 (16.0%) of 187 infants who were screened. Increased length of stay in the nursery (P

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Published in:The Journal of infectious diseases 1988-08, Vol.158 (2), p.349-354
Main Authors: Bacon, Alfred E., Fekety, Robert, Schaberg, Dennis R., Faix, Roger G.
Format: Article
Language:English
Subjects:
Bacterial colonization
Bacterial Proteins
Bacterial Toxins - metabolism
Bacterial typing techniques
Bacteriocins
Bacteriology
Bacteriophage Typing
Bacteriophages
Biological and medical sciences
Cesarean section
Clostridium - classification
Clostridium - isolation & purification
Clostridium difficile
Delivery, Obstetric
Environmental Microbiology
Epidemiology
Feces - microbiology
Fundamental and applied biological sciences. Psychology
Hand - microbiology
Health Workforce
Humans
Infant, Newborn - microbiology
Infants
Length of stay
Microbial colonization
Microbiology
Nurseries, Hospital
Original Articles
Toxins
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container_end_page 354
container_issue 2
container_start_page 349
container_title The Journal of infectious diseases
container_volume 158
creator Bacon, Alfred E.
Fekety, Robert
Schaberg, Dennis R.
Faix, Roger G.
description We used a typing system based on bacteriophage and bacteriocin susceptibility to study the epidemiology of Clostridium difficile colonization of newborn infants. C. difficile was found in the stools of 30 (16.0%) of 187 infants who were screened. Increased length of stay in the nursery (P
doi_str_mv 10.1093/infdis/158.2.349
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C. difficile was found in the stools of 30 (16.0%) of 187 infants who were screened. Increased length of stay in the nursery (P &lt;.001) and delivery by cesarian section (P &lt;.001) were associated with higher rates of colonization. The isolates initially detected from the environment and the infants were strain B1811-1700. Strain B1537/Cld7 became the predominant isolate obtained from the infants; positive cultures were also obtained from the environment and the hands of personnel who worked in the nursery and had strain B1537/Cld7. 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C. difficile was found in the stools of 30 (16.0%) of 187 infants who were screened. Increased length of stay in the nursery (P &lt;.001) and delivery by cesarian section (P &lt;.001) were associated with higher rates of colonization. The isolates initially detected from the environment and the infants were strain B1811-1700. Strain B1537/Cld7 became the predominant isolate obtained from the infants; positive cultures were also obtained from the environment and the hands of personnel who worked in the nursery and had strain B1537/Cld7. Our results suggest that the infants acquired C. difficile through transfer from the hands of hospital staff.</description><subject>Bacterial colonization</subject><subject>Bacterial Proteins</subject><subject>Bacterial Toxins - metabolism</subject><subject>Bacterial typing techniques</subject><subject>Bacteriocins</subject><subject>Bacteriology</subject><subject>Bacteriophage Typing</subject><subject>Bacteriophages</subject><subject>Biological and medical sciences</subject><subject>Cesarean section</subject><subject>Clostridium - classification</subject><subject>Clostridium - isolation &amp; purification</subject><subject>Clostridium difficile</subject><subject>Delivery, Obstetric</subject><subject>Environmental Microbiology</subject><subject>Epidemiology</subject><subject>Feces - microbiology</subject><subject>Fundamental and applied biological sciences. 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C. difficile was found in the stools of 30 (16.0%) of 187 infants who were screened. Increased length of stay in the nursery (P &lt;.001) and delivery by cesarian section (P &lt;.001) were associated with higher rates of colonization. The isolates initially detected from the environment and the infants were strain B1811-1700. Strain B1537/Cld7 became the predominant isolate obtained from the infants; positive cultures were also obtained from the environment and the hands of personnel who worked in the nursery and had strain B1537/Cld7. Our results suggest that the infants acquired C. difficile through transfer from the hands of hospital staff.</abstract><cop>Chicago, IL</cop><pub>The University Chicago Press</pub><pmid>3403992</pmid><doi>10.1093/infdis/158.2.349</doi><tpages>6</tpages></addata></record>
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source JSTOR Archival Journals and Primary Sources Collection; Oxford University Press Archive
subjects Bacterial colonization
Bacterial Proteins
Bacterial Toxins - metabolism
Bacterial typing techniques
Bacteriocins
Bacteriology
Bacteriophage Typing
Bacteriophages
Biological and medical sciences
Cesarean section
Clostridium - classification
Clostridium - isolation & purification
Clostridium difficile
Delivery, Obstetric
Environmental Microbiology
Epidemiology
Feces - microbiology
Fundamental and applied biological sciences. Psychology
Hand - microbiology
Health Workforce
Humans
Infant, Newborn - microbiology
Infants
Length of stay
Microbial colonization
Microbiology
Nurseries, Hospital
Original Articles
Toxins
title Epidemiology of Clostridium difficile Colonization in Newborns: Results Using a Bacteriophage and Bacteriocin Typing System
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