Gastric Mucosa Abnormalities and Tumorigenesis in Mice Lacking the pS2 Trefoil Protein

The mechanisms that maintain the epithelial integrity of the gastrointestinal tract remain largely undefined. The gene encoding intestinal trefoil factor (ITF), a protein secreted throughout the small intestine and colon, was rendered nonfunctional in mice by targeted disruption. Mice lacking ITF ha...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1996-10, Vol.274 (5285), p.259-262
Main Authors: Lefebvre, Olivier, Chenard, Marie-Pierre, Masson, Régis, Linares, José, Dierich, Andrée, LeMeur, Marianne, Wendling, Corinne, Tomasetto, Catherine, Chambon, Pierre, Rio, Marie-Christine
Format: Article
Language:English
Subjects:
Adenoma
Adenoma - etiology
Adenoma - pathology
Animals
Base Sequence
Biological and medical sciences
Carcinogenesis
Cell Differentiation
Classical genetics, quantitative genetics, hybrids
Cloning, Molecular
DNA
Epithelial cells
Female
Fundamental and applied biological sciences. Psychology
Gastric mucosa
Gastric Mucosa - cytology
Gastric Mucosa - pathology
Gene Targeting
Genes
Genes, Tumor Suppressor
Genetic aspects
Genetics of eukaryotes. Biological and molecular evolution
Individualized Instruction
Intestinal Mucosa - cytology
Intestinal Mucosa - pathology
Intestines
Male
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Mucosa
Mutation
Neoplasm Proteins - genetics
Neoplasm Proteins - physiology
Phenotype
Proteins
Pyloric Antrum
RNA
Rodents
Small intestine
Stomach
Stomach Neoplasms - etiology
Stomach Neoplasms - pathology
Transcripts (Written Records)
Trefoil Factor-1
Tumor suppressor genes
Tumor Suppressor Proteins
Vertebrata
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Description
Summary:The mechanisms that maintain the epithelial integrity of the gastrointestinal tract remain largely undefined. The gene encoding intestinal trefoil factor (ITF), a protein secreted throughout the small intestine and colon, was rendered nonfunctional in mice by targeted disruption. Mice lacking ITF had impaired mucosal healing and died from extensive colitis after oral administration of dextran sulfate sodium, an agent that causes mild epithelial injury in wild-type mice. ITF-deficient mice manifested poor epithelial regeneration after injury. These findings reveal a central role for ITF in the maintenance and repair of the intestinal mucosa.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.274.5285.259