ACTINOPLANONES C, D, E, F AND G, NEW CYTOTOXIC POLYCYCLIC XANTHONES FROM ACTINOPLANES SP

Our previous finding of strong cytotoxic polycyclic xanthones, actinoplanones A (1) and B (2), in the culture broth of Actinoplanes sp. R-304 stimulated us to isolate further five new cytotoxic polycyclic xanthones which were named actinoplanones C (3), D (4), E (5), F (6) and G (7) from the broth....

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Bibliographic Details
Published in:Journal of antibiotics 1988/06/25, Vol.41(6), pp.741-750
Main Authors: KOBAYASHI, KOJI, NISHINO, CHIKAO, OHYA, JUNICHI, SATO, SHIGERU, MIKAWA, TAKASHI, SHIOBARA, YOSHINORI, KODAMA, MITSUAKI
Format: Article
Language:English
Subjects:
Actinomycetales - metabolism
Actinoplanes
actinoplanones
Antibiotics, Antineoplastic - isolation & purification
Antibiotics, Antineoplastic - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
Biological and medical sciences
Chemical Phenomena
Chemistry
DNA - biosynthesis
Medical sciences
Miscellaneous. Antibiotics with multiple activities
Pharmacology. Drug treatments
Protein Biosynthesis
Structure-Activity Relationship
Xanthenes - isolation & purification
Xanthenes - pharmacology
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Summary:Our previous finding of strong cytotoxic polycyclic xanthones, actinoplanones A (1) and B (2), in the culture broth of Actinoplanes sp. R-304 stimulated us to isolate further five new cytotoxic polycyclic xanthones which were named actinoplanones C (3), D (4), E (5), F (6) and G (7) from the broth. Actinoplanones C (3) and G (7) showed very strong cytotoxicity against HeLa cells at less than 0.00004 μg/ml dosage (IC50). The structures of 3-7 were varieties of 1 for the N-2 and C-4 substituents. All or several actinoplanones showed strong antimicrobial activities against bacteria and the rice blast fungus. Actinoplanone A (1) was tested for cytotoxicity against various tumor cells and for inhibitory effect on HeLa cell macromolecular synthesis, and 1 exhibited strong cytotoxicity against the cells and inhibitory action on DNA synthesis.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.41.741