A83586C, A NEW DEPSIPEPTIDE ANTIBIOTIC

A culture identified as Streptomyces karnatakensis was found to produce a novel cyclic hexadepsipeptide antibiotic designated A83586C. The structure was elucidated by X-ray crystallography, and full 1H and 13C NMR assignments are reported. The absolute configuration was confirmed by the detection of...

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Bibliographic Details
Published in:Journal of antibiotics 1988/06/25, Vol.41(6), pp.726-733
Main Authors: SMITKA, TIM A., DEETER, JACK B., HUNT, ANN H., MERTZ, FREDERICK P., ELLIS, ROBERT M., BOECK, LAVERNE D., YAO, RAYMOND C.
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Depsipeptides
Fermentation
Mice
Molecular Conformation
Peptides
Peptides, Cyclic - isolation & purification
Streptomyces - classification
Streptomyces - metabolism
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Summary:A culture identified as Streptomyces karnatakensis was found to produce a novel cyclic hexadepsipeptide antibiotic designated A83586C. The structure was elucidated by X-ray crystallography, and full 1H and 13C NMR assignments are reported. The absolute configuration was confirmed by the detection of D-threonine in the acid hydrolysate of A83586C. A83586C had potent Gram-positive activity in vitro but lacked in vivo efficacy in mice.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.41.726