Neuronal lesions and behavioral modifications in rat following cerebral ischemia and reperfusion

Neurons of the mammalian CNS differ in their vulnerability to various disease processes and other insults, particularly in their response to total anoxia/ischemia. In this study we have tested the histological and behavioral modifications induced by experimental conditions of partial cerebral ischem...

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Bibliographic Details
Published in:Neurochemical research 1996-06, Vol.21 (6), p.667-674
Main Authors: MARTINEZ, G, CARNAZZA, M. L, DI GIACOMO, C, SORRENTI, V, CASTANA, R, PENNISI, G, PEREZ-POLO, J. R, VANELLA, A
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain Ischemia - physiopathology
Evaluation Studies as Topic
Learning - physiology
Male
Medical sciences
Motor Activity - physiology
Neurology
Neurons - physiology
Neurons - ultrastructure
Rats
Rats, Wistar
Reperfusion Injury - physiopathology
Vascular diseases and vascular malformations of the nervous system
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Summary:Neurons of the mammalian CNS differ in their vulnerability to various disease processes and other insults, particularly in their response to total anoxia/ischemia. In this study we have tested the histological and behavioral modifications induced by experimental conditions of partial cerebral ischemia in the rats. The specific morphological and histological alterations, observed in our experimental conditions of reversible partial cerebral ischemia, confirm the selective vulnerability of certain neuronal populations to ischemic injury and are also evidenced by behavioral modifications which may mirror the functional impairment observed in humans after a transitory ischemic attack.
ISSN:0364-3190
1573-6903
DOI:10.1007/BF02527723