How Tat targets TAR: structure of the BIV peptide–RNA complex

Two new NMR structures describing the complex formed by a peptide from the BIV Tat protein with the TAR RNA provide a significant advance in our understanding of the ways in which peptides interact with specific sites in the major groove of their RNA targets.

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Bibliographic Details
Published in:Structure 1996-01, Vol.4 (1), p.5-9
Main Author: Greenbaum, Nancy L
Format: Article
Language:English
Subjects:
AIDS/HIV
Amino Acid Sequence
Animals
Base Sequence
Cattle
Gene Products, tat - chemistry
Gene Products, tat - metabolism
HIV-1 - chemistry
Immunodeficiency Virus, Bovine - metabolism
Magnetic Resonance Spectroscopy
Models, Molecular
Molecular Sequence Data
Nucleic Acid Conformation
Protein Conformation
RNA - chemistry
RNA - metabolism
RNA-Binding Proteins - chemistry
RNA-Binding Proteins - metabolism
tat Gene Products, Human Immunodeficiency Virus
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Description
Summary:Two new NMR structures describing the complex formed by a peptide from the BIV Tat protein with the TAR RNA provide a significant advance in our understanding of the ways in which peptides interact with specific sites in the major groove of their RNA targets.
ISSN:0969-2126
1878-4186
DOI:10.1016/S0969-2126(96)00003-2