Translocation t(X;18) in orofacial synovial sarcoma

Cytogenetic analysis of a synovial sarcoma of the base of the tongue showed a reciprocal translocation involving chromosomes X and 18 [t(X;18)(p11.2;q11.2)]. This is a translocation recently reported to be characteristic of synovial sarcomas of the extremities. The histogenesis of synovial sarcoma i...

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Bibliographic Details
Published in:Cancer 1988-09, Vol.62 (5), p.935-937
Main Authors: Bridge, Julia A., Bridge, Robert S., Borek, Deborah A., Shaffer, Barbara, Norris, Charley W.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Chromosomes, Human, Pair 18
Facial bones, jaws, teeth, parodontium: diseases, semeiology
Humans
Karyotyping
Male
Medical sciences
Otorhinolaryngology. Stomatology
Sarcoma, Synovial - genetics
Tongue Neoplasms - genetics
Translocation, Genetic
Tumors
X Chromosome
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Summary:Cytogenetic analysis of a synovial sarcoma of the base of the tongue showed a reciprocal translocation involving chromosomes X and 18 [t(X;18)(p11.2;q11.2)]. This is a translocation recently reported to be characteristic of synovial sarcomas of the extremities. The histogenesis of synovial sarcoma is controversial. Our discovery of this translocation in an oral synovial sarcoma confirms the unity of origin of this neoplasm with the far more common synovial sarcomas of the extremity. Karyotypic analysis may prove useful in confirming the diagnosis of this uncommon neoplasm.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19880901)62:5<935::AID-CNCR2820620514>3.0.CO;2-E