Treatment with acyclovir does not affect orogenital ulcers in Behçet's syndrome: a randomized double-blind trial

Acyclovir is a potent antiviral drug, of proven efficacy in the treatment of herpes simplex virus infection. Since this virus has been implicated in the aetiology of Behçet's syndrome, the effect of acyclovir on orogenital ulceration in this condition was determined in a randomized, double-blin...

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Bibliographic Details
Published in:British journal of rheumatology 1988-08, Vol.27 (4), p.300-302
Main Authors: DAVIES, U. M, PALMER, R. G, DENMAN, A. M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Behcet Syndrome - complications
Biological and medical sciences
Clinical Trials as Topic
Double-Blind Method
Female
Genital Diseases, Female - complications
Genital Diseases, Female - drug therapy
Genital Diseases, Male - complications
Genital Diseases, Male - drug therapy
Humans
Male
Medical sciences
Middle Aged
Mouth Diseases - complications
Mouth Diseases - drug therapy
Pharmacology. Drug treatments
Random Allocation
Ulcer - complications
Ulcer - drug therapy
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Summary:Acyclovir is a potent antiviral drug, of proven efficacy in the treatment of herpes simplex virus infection. Since this virus has been implicated in the aetiology of Behçet's syndrome, the effect of acyclovir on orogenital ulceration in this condition was determined in a randomized, double-blind, placebo-controlled, crossover trial. Eighteen of 22 patients entering the study completed the trial. Treatment with acyclovir failed to alleviate the frequency and severity of orogenital ulceration or other disease features.
ISSN:0263-7103
1460-2172