TRH-like immunoreactivity in endocrine cells and neurons in the gastro-intestinal tract of the rat and guinea pig

By use of the indirect immunofluorescence technique, the cellular localization of thyrotropin-releasing hormone (TRH) was studied in the gastrointestinal tract of rats and guinea pigs of different ages. TRH-like immunoreactivity (LI) was observed in many pancreatic islet cells of young rats and guin...

Full description

Saved in:
Bibliographic Details
Published in:Cell and tissue research 1988-08, Vol.253 (2), p.347-356
Main Authors: TSURUO, Y, HOKFELT, T, VISSER, T. J, KIMMEL, J. R, BROWN, J. C, VERHOFSTADT, A, WALSH, J
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Digestive System - analysis
Digestive System - innervation
Endocrine Glands - analysis
Fundamental and applied biological sciences. Psychology
Guinea Pigs
Hormones and neuropeptides. Regulation
Hypothalamus. Hypophysis. Epiphysis. Urophysis
Immunohistochemistry
Islets of Langerhans - analysis
Islets of Langerhans - metabolism
Male
Rats
Stomach - analysis
Stomach - innervation
Thyrotropin-Releasing Hormone - analysis
Vertebrates: endocrinology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:By use of the indirect immunofluorescence technique, the cellular localization of thyrotropin-releasing hormone (TRH) was studied in the gastrointestinal tract of rats and guinea pigs of different ages. TRH-like immunoreactivity (LI) was observed in many pancreatic islet cells of young rats and guinea pigs but only in single cells of 6-month-old rats. In aged guinea pigs, a reduction in the number of TRH-positive cells was evident; however, numerous strongly fluorescent cells were still present. In the guinea pig, TRH-LI was in addition observed in gastrin cells in the stomach. TRH-positive nerve fibers occurred in the myenteric plexus of the oesophagus, stomach and intestine of the rat, and in the muscle layers of the guinea pig. These results suggest a functional role of TRH both as hormone and neuroactive compound in various portions and sites of the gastro-intestinal tract of the rat and guinea pig.
ISSN:0302-766X
1432-0878
DOI:10.1007/BF00222291