Penicillin-Resistant Aerococcus viridans Bacteremia in a Child Receiving Prophylaxis for Sickle-Cell Disease

We report of a case of Aerococcus viridans bacteremia in a child who was receiving prophylactic penicillin for sickle-cell disease (SCD); to our knowledge, this is only the second reported case of infection due to a penicillin-resistant strain. An 11-month-old black female with SCD presented to the...

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Bibliographic Details
Published in:Clinical infectious diseases 1996-02, Vol.22 (2), p.387-388
Main Authors: Swanson, Holly, Cutts, Ethan, Lepow, Martha
Format: Article
Language:English
Subjects:
Aerococcus
Aerococcus viridans
Anemia, Sickle Cell - prevention & control
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacteremia
Bacteremia - drug therapy
Bacteremia - microbiology
Bacterial diseases
Biological and medical sciences
Blood
Brief Reports
Cephalexin - therapeutic use
Cephalosporins - therapeutic use
Female
Humans
Infant
Infections
Infectious diseases
Medical sciences
Pathogens
Pediatrics
Penicillin
Penicillin Resistance
Penicillins - therapeutic use
Pharmacology. Drug treatments
Preventive medicine
Streptococcaceae - isolation & purification
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Summary:We report of a case of Aerococcus viridans bacteremia in a child who was receiving prophylactic penicillin for sickle-cell disease (SCD); to our knowledge, this is only the second reported case of infection due to a penicillin-resistant strain. An 11-month-old black female with SCD presented to the emergency department with a rectal temperature of 103 degree F. She was receiving prophylactic penicillin (125 mg) twice daily. Urine and blood for cultures were obtained; she received a single dose of im ceftriaxone (50 mg/kg) and was discharged. The following day, the patient returned to the clinic; she appeared well but had a temperature to 100.7 degree F. She again received im ceftriaxone (50 mg/kg) and was sent home. Later that day, cultures of the blood obtained 29 hours earlier yielded gram-positive cocci in clusters. She was recalled for admission to the hospital, and the results of physical examination were unchanged, as were the laboratory values. Culture of blood was repeated, and the patient was treated with iv cefuroxime. The organism was identified as beta -lactamase-negative A. viridans.
ISSN:1058-4838
1537-6591
DOI:10.1093/clinids/22.2.387