Synthetic magainin analogues with improved antimicrobial activity

Based on modifications to enhance the α-helical structure of the broad spectrum antibiotic magainin 2, a series of analogues have been synthesized which display an increase up to two orders of magnitude in antimicrobial activity and, in the most favorable case, no appreciable increase in hemolytic a...

Full description

Saved in:
Bibliographic Details
Published in:FEBS letters 1988-08, Vol.236 (2), p.462-466
Main Authors: Chen, Hao-Chia, Brown, Judith H., Morell, John L., Huang, C.M.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Amphiphilic helix
Animals
Anti-Infective Agents
Antibiotic activity
Antimicrobial Cationic Peptides
Circular Dichroism
Magainins
Molecular Sequence Data
Peptide design
peptide synthesis
Peptides - chemical synthesis
Protein Conformation
Structure-Activity Relationship
Structure-function relationship
Xenopus laevis
Xenopus Proteins
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Based on modifications to enhance the α-helical structure of the broad spectrum antibiotic magainin 2, a series of analogues have been synthesized which display an increase up to two orders of magnitude in antimicrobial activity and, in the most favorable case, no appreciable increase in hemolytic activity over magainin 1 at the concentrations tested.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(88)80077-2