BK and JC Virus Infections in Recipients of Bone Marrow Transplants

Fifty-five recipients of bone marrow transplants were monitored prospectively for urinary excretion of BK (BKV) and JC (JCV) viruses and for infections with other viruses. For both BKV and JCV, viruria occurred exclusively in patients who were seropositive at transplantation, a finding indicating th...

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Bibliographic Details
Published in:The Journal of infectious diseases 1988-09, Vol.158 (3), p.563-569
Main Authors: Arthur, Ray R., Shah, Keerti V., Charache, Patricia, Saral, Rein
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Antibodies
Antibodies, Viral - analysis
Biological and medical sciences
BK Virus - immunology
BK Virus - isolation & purification
Bone marrow
Bone Marrow Transplantation
Bone marrow, stem cells transplantation. Graft versus host reaction
Cystitis
Cytomegalovirus Infections - etiology
Excretion
Herpes Simplex - etiology
Humans
Infections
JC virus
JC Virus - immunology
JC Virus - isolation & purification
Medical sciences
Original Articles
Prospective Studies
Recurrence
Specimens
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Transplantation
Tumor Virus Infections - etiology
Tumor Virus Infections - microbiology
Tumor Virus Infections - urine
Urinary Tract Infections - etiology
Urinary Tract Infections - microbiology
Urinary Tract Infections - urine
Urine
Urine - microbiology
Viruses
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Summary:Fifty-five recipients of bone marrow transplants were monitored prospectively for urinary excretion of BK (BKV) and JC (JCV) viruses and for infections with other viruses. For both BKV and JCV, viruria occurred exclusively in patients who were seropositive at transplantation, a finding indicating that shedding of virus was very likely the result of reactivation. BKV reactivation, which occurred in 26 (55%) of 47 BKV-seropositive patients, was far more common than JCV reactivation, which was detected in only two (7%) of 30 JCV-seropositive patients (P < .0001). In most patients, BK viruria began two to eight weeks after transplantation and resolved spontaneously after a two- to three week period. Posttransplantation, there was a temporal pattern in the onsets of infection with the different viruses; herpes simplex virus infections occurred first (mean, 7 d), followed by BKV infections (mean, 33d) and then cytomegalovirus infections (mean, 51d). BK viruria was associated with hemorrhagic cystitis.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/158.3.563