Interleukin-10 (IL-10) secretion in systemic lupus erythematosus and rheumatoid arthritis : IL-10-dependent CD4+CD45RO+ T cell-B cell antibody synthesis

• Published in: Journal of clinical immunology 1996-07, Vol.16 (4), p.198-207
• Main Authors: AL-JANADI, M, AL-DALAAN, A, AL-BALLA, S, AL-HUMAIDI, M, RAZIUDDIN, S
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; AIDS/HIV; Arthritis, Rheumatoid - complications; Arthritis, Rheumatoid - immunology; B-Lymphocytes - drug effects; B-Lymphocytes - immunology; Biological and medical sciences; CD4-Positive T-Lymphocytes - drug effects; CD4-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - drug effects; CD8-Positive T-Lymphocytes - metabolism; Diseases of the osteoarticular system; Female; Humans; Hypergammaglobulinemia - etiology; Inflammatory joint diseases; Interferon-gamma - antagonists & inhibitors; Interleukin-10 - antagonists & inhibitors; Interleukin-10 - immunology; Interleukin-6 - antagonists & inhibitors; Leukocyte Common Antigens - drug effects; Leukocyte Common Antigens - immunology; Lupus Erythematosus, Systemic - complications; Lupus Erythematosus, Systemic - immunology; Male; Medical sciences; Middle Aged; Monocytes - drug effects; Monocytes - metabolism; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
• ISSN: 0271-9142; 1573-2592
• DOI: 10.1007/BF01541225

Interleukin-10 (IL-10) is a major immunoregulatory cytokine and has a multitude of immunomodulatory effects in the immune system. In this study, we have examined the secretion and in vitro function of IL-10 in B cell hyperactivity in antibody production in two common autoimmune diseases, systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). IL-10 was detectable in serum of all active SLE and serum and synovial fluid samples of all RA patients but in none of the normal controls. B cells and CD4+CD45RO+ "memory" T cells secreted highly enhanced levels of IL-10 in SLE and RA versus normals. Increased IgM and IgG production by B cells-CD4+CD45RO+ T cells in SLE and RA was IL-10 dependent, since neutralization of IL-10 cytokine by anti-IL-10 antibody drastically reduced Ig synthesis in these coculture experiments. B cell hyperactivity in autoantibody production in SLE and RA may be a function of IL-10-dependent CD4+CD45RO+ Th2 cell activation. Therefore, IL-10 may play an important role in highly disturbed immune system and B cell-T cell function in these immune disorders.