Salmon Calcitonin Induced Head Twitch in the Rat

The intracerebroventricular administration of salmon calcitonin (sCT) to rats induced a dose-dependent increase in the number of head twitches and potentiated such a response elicited by L-5-hydroxytryptophan (L-5-HTP). Subcutaneously administered sCT was ineffective “per se” but could again potenti...

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Bibliographic Details
Published in:Japanese journal of pharmacology 1988, Vol.47(1), pp.87-90
Main Authors: GAGGI, Renato, IASIO, Rosaria DE
Format: Article
Language:English
Subjects:
5-Hydroxytryptophan - metabolism
Animals
Behavior, Animal - drug effects
Biological and medical sciences
Brain - drug effects
Brain - metabolism
Calcitonin - administration & dosage
Calcitonin - pharmacology
Dose-Response Relationship, Drug
Hormones. Endocrine system
Hydroxyindoleacetic Acid - metabolism
Injections, Intraventricular
Injections, Subcutaneous
Male
Medical sciences
Pharmacology. Drug treatments
Rats
Rats, Inbred Strains
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Summary:The intracerebroventricular administration of salmon calcitonin (sCT) to rats induced a dose-dependent increase in the number of head twitches and potentiated such a response elicited by L-5-hydroxytryptophan (L-5-HTP). Subcutaneously administered sCT was ineffective “per se” but could again potentiate the head twitch response elicited by L-5-HTP. Since these data suggest a stimulation of the brain serotonergic pathways, the obtained results support the hypothesis that some central actions of sCT may involve activation of serotonergic systems in the rat brain.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.47.87