Cryptococcus neoformans Infection in France: Epidemiologic Features of and Early Prognostic Parameters for 76 Patients Who Were Infected with Human Immunodeficiency Virus

We retrospectively carried out a descriptive and prognostic study of 76 human immunodeficiency virus-infected patients with cryptococcosis diagnosed by a positive culture of cerebrospinal fluid (CSF), blood, urine, or other body fluid or tissue. We focused on the 65 patients with cryptococcal mening...

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Bibliographic Details
Published in:Clinical infectious diseases 1996-08, Vol.23 (2), p.369-376
Main Authors: Darras-Joly, Clémence, Chevret, Sylvie, Wolff, Michel, Matheron, Sophie, Longuet, Pascale, Casalino, Enrique, Joly, Véronique, Chochillon, Christian, Bédos, Jean-Pierre
Format: Article
Language:English
Subjects:
Adult
Aged
AIDS
AIDS-Related Opportunistic Infections - epidemiology
AIDS-Related Opportunistic Infections - physiopathology
AIDS-Related Opportunistic Infections - therapy
AIDS/HIV
Antigens
Biological and medical sciences
Cryptococcal meningitis
Cryptococcosis
Cryptococcus neoformans
Cryptococcus neoformans - isolation & purification
Female
Fever
France - epidemiology
Headache
Health outcomes
Hospital admissions
human immunodeficiency virus
Human mycoses
Humans
Infections
Infectious diseases
Intensive care units
International Report
Male
Medical sciences
Meningitis, Cryptococcal - epidemiology
Meningitis, Cryptococcal - physiopathology
Meningitis, Cryptococcal - therapy
Middle Aged
Mycoses
Mycoses of the respiratory system
Prognosis
Retrospective Studies
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Summary:We retrospectively carried out a descriptive and prognostic study of 76 human immunodeficiency virus-infected patients with cryptococcosis diagnosed by a positive culture of cerebrospinal fluid (CSF), blood, urine, or other body fluid or tissue. We focused on the 65 patients with cryptococcal meningitis. At diagnosis, the mean CD4 lymphocyte count was 46/mm3; 86% of patients had fever; 67%, headache; 37%, stiff neck; 29%, altered mentation or confusion; 20% cranial nerve deficiency; and 48%, other focal deficiencies. Analysis of CSF specimens revealed the following results: normal (25% of the specimens), leukocyte count of
ISSN:1058-4838
1537-6591
DOI:10.1093/clinids/23.2.369