Identification of an Asymmetrically Localized Sensor Histidine Kinase Responsible for Temporally and Spatially Regulated Transcription

Caulobacter crescentus undergoes asymmetric cell division, resulting in a stalked cell and a motile swarmer cell. The genes encoding external components of the flagellum are expressed in the swarmer compartment of the predivisional cell through the localized activation of the transcription factor FI...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1996-10, Vol.274 (5287), p.597-601
Main Authors: Wingrove, James A., Gober, James W.
Format: Article
Language:English
Subjects:
Amino acids
Antibodies
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Bacteriology
Biochemistry
Biological and medical sciences
Caulobacter crescentus
Caulobacter crescentus - cytology
Caulobacter crescentus - genetics
Caulobacter crescentus - physiology
Cell cycle
Cell Division
Cell regulation
Cells
Cellular control mechanisms
Cellular signal transduction
Developmental Programs
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Bacterial
Genes
Genes, Bacterial
Genetic regulation
Genetic transcription
Genetics
Histidine Kinase
Microbiology
Mutation
Operator regions
Phosphates
Phosphorylation
Plasmids
Promoter Regions, Genetic
Protein Kinases - genetics
Protein Kinases - metabolism
Recombinant Fusion Proteins - metabolism
Regulation
Transcription (Genetics)
Transcription Factors - genetics
Transcription Factors - metabolism
Transcription, Genetic
Transcriptional regulatory elements
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Summary:Caulobacter crescentus undergoes asymmetric cell division, resulting in a stalked cell and a motile swarmer cell. The genes encoding external components of the flagellum are expressed in the swarmer compartment of the predivisional cell through the localized activation of the transcription factor FIbD. The mechanisms responsible for the temporal and spatial activation of FIbD were determined through identification of FIbE, a histidine kinase required for FIbD activity. FIbE is asymmetrically distributed in the predivisional cell. It is located at the pole of the stalked compartment and at the site of cell division in the swarmer compartment. These findings suggest that FIbE and FIbD are activated in response to a morphological change in the cell resulting from cell division events.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.274.5287.597