SPINAL ANAESTHESIA WITH HYPERBARIC BUPIVACAINE: EFFECTS OF CONCENTRATION AND VOLUME WHEN ADMINISTERED IN THE SITTING POSITION

In a double blind study, solutions of 0.5% or 0.75% bupivacaine containing 8% dextrose were compared with regard to the effect of varying concentration and volume when administered intrathecally to patients in the sitting position. Ten patients received 3 or 4 ml of 0.5% bupivacaine or 2 or 3 mi of...

Full description

Saved in:
Bibliographic Details
Published in:British journal of anaesthesia : BJA 1988-08, Vol.61 (2), p.144-148
Main Authors: ALSTON, R.P., LITTLEWOOD, D.G., MEEK, R, EDSTRÖM, H.H.
Format: Article
Language:English
Subjects:
Aged
Anesthesia
Anesthesia, Spinal
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Bupivacaine - administration & dosage
Bupivacaine - pharmacology
Humans
Local anesthesia. Pain (treatment)
Male
Medical sciences
Posture
Specific Gravity
Time Factors
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In a double blind study, solutions of 0.5% or 0.75% bupivacaine containing 8% dextrose were compared with regard to the effect of varying concentration and volume when administered intrathecally to patients in the sitting position. Ten patients received 3 or 4 ml of 0.5% bupivacaine or 2 or 3 mi of 0.75% bupivacaine. Nine patients received 0.5% bupivacaine 2 ml and another nine received 0.75% bupivacaine 1.3ml. The use of the 10-mg dose of both solutions was abandoned after nine patients in each group becafse of insufficient cephalad spread. With both solutions, the smallest volumes (bupivacaine 10 mg) had significantly shorter durations of action than both the larger ones (15–20/22.5 mg), between which there were no significant differences.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/61.2.144