Insulin treatment of the insulin-dependent diabetic patient undergoing minor surgery: continuous intravenous infusion compared with subcutaneous administration

In a prospective randomised study in 20 insulin-dependent diabetics who had minor surgery under general anaesthesia we compared the metabolic responses to intravenous glucose-insulin-potassium infusion with those who had conventional subcutaneous insulin administration. The former treatment resulted...

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Bibliographic Details
Published in:Anaesthesia 1988-07, Vol.43 (7), p.533-537
Main Authors: CHRISTIANSEN, C. L, SCHURIZEK, B. A, MALLING, B, KNUDSEN, L, ALBERTI, K. G. M. M, HERMANSEN, K
Format: Article
Language:English
Subjects:
Adult
Aged
Anesthesia
Anesthesia depending on patient's condition
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Blood Glucose - analysis
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - drug therapy
Female
Glucose - administration & dosage
Glucose - therapeutic use
Humans
Infusions, Intravenous
Injections, Subcutaneous
Insulin - administration & dosage
Insulin - therapeutic use
Male
Medical sciences
Middle Aged
Minor Surgical Procedures
Potassium - administration & dosage
Potassium - therapeutic use
Prospective Studies
Random Allocation
Citations: Items that this one cites
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Summary:In a prospective randomised study in 20 insulin-dependent diabetics who had minor surgery under general anaesthesia we compared the metabolic responses to intravenous glucose-insulin-potassium infusion with those who had conventional subcutaneous insulin administration. The former treatment resulted in lower blood glucose levels both during the infusion period (p less than 0.05) as well as the entire observation period (operative, first and second postoperative days; p less than 0.01). More blood glucose values were within the intended range of 5 to 10 mmol/litre in the glucose-insulin-potassium as compared to the conventional group (48% versus 24%; p less than 0.01). The levels of lactate, 3-hydroxybutyrate, glycerol, alanine, glucagon, insulin and growth hormone did not differ between the two groups. The infusion regimen resulted in better glycaemic control both peri-and postoperatively than the conventional subcutaneous insulin regimen in insulin-dependent diabetic patients who have minor surgery.
ISSN:0003-2409
1365-2044
DOI:10.1111/j.1365-2044.1988.tb06681.x