Leukocyte-endothelial adhesion and angiogenesis in tumors

Leukocyte-endothelial adhesion and angiogenesis, until recently considered as separate processes, have been shown to be linked by two recent findings: soluble cellular adhesion molecules (CAMs) involved in leukocyte-endothelial interactions are angiogenic and well known angiogenic molecules secreted...

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Bibliographic Details
Published in:Cancer and metastasis reviews 1996-06, Vol.15 (2), p.195-204
Main Authors: Jain, R K, Koenig, G C, Dellian, M, Fukumura, D, Munn, L L, Melder, R J
Format: Article
Language:English
Subjects:
Animals
Cell Adhesion - physiology
Cell Adhesion Molecules - physiology
Cell Communication - physiology
Endothelium, Vascular - cytology
Humans
Leukocytes - cytology
Neoplasms - blood supply
Neovascularization, Pathologic - pathology
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Summary:Leukocyte-endothelial adhesion and angiogenesis, until recently considered as separate processes, have been shown to be linked by two recent findings: soluble cellular adhesion molecules (CAMs) involved in leukocyte-endothelial interactions are angiogenic and well known angiogenic molecules secreted by cancer or immune. cells can modulate the endothelial CAMs. This molecular link may partially explain why the overall leukocyte-endothelial interaction is often low and heterogeneous in angiogenic tumor vessels and why activated lymphocytes adhere nonuniformly to tumor vessels when injected into the tumor's blood supply.
ISSN:0167-7659
1573-7233
DOI:10.1007/BF00437472