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Antiplatelet and calcium inhibitory properties of eugenol and sodium eugenol acetate

1. 1. Eugenol (3-methoxy-4-hydroxy-propenylbenzene) or sodium eugenol acetate (4-0-acetic acid sodium-3-methoxy-l-propenylbenzene) (0.25, 0.5, 1 mM) concentration-dependently inhibited arachidonic acid (AA)., collagen-, epinephrine- and ADP-induced platelet aggregation. 2. 2. Eugenol or sodium eugen...

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Published in:General pharmacology 1996-06, Vol.27 (4), p.629-633
Main Authors: Chen, Sheue-Jiun, Wang, Ming-Hsin, Chen, Ing-Jun
Format: Article
Language:English
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Summary:1. 1. Eugenol (3-methoxy-4-hydroxy-propenylbenzene) or sodium eugenol acetate (4-0-acetic acid sodium-3-methoxy-l-propenylbenzene) (0.25, 0.5, 1 mM) concentration-dependently inhibited arachidonic acid (AA)., collagen-, epinephrine- and ADP-induced platelet aggregation. 2. 2. Eugenol or sodium eugenol acetate inhibited collagen-induced aggregation of washed rabbit platelets synergistically with creatine phosphatelcreatine phosphokinase (CP/CPK, 5 mM/10 U/ml) or p-bromophenacyl bromide (p-BPB, 10 μM), and they also potentiated the inhibitory action of imidazole (0.5 mM) on AA-induced aggregation. 3. 3. Eugenol or sodium eugenol acetate (0.25, 0.5, 1 mM) concentration-dependently inhibited AA-induced thromboxane B 2 and prostaglandin E 2 formation. 4. 4. The rise of intracellular Ca 2+ caused by collagen, epinephrine, ADP, and AA were inhibited by eugenol or sodium eugenol acetate (1 mM).
ISSN:0306-3623
1879-0011
DOI:10.1016/0306-3623(95)02089-6