A new role for CD23 in inflammation

CD23, is expressed on a variety of haematopoietic cell types and displays pleiotropic activities in vitro. Here Jean-Yves Bonnefoy and collegues discuss a novel interaction between CD23 and the α chains of the β 2 integrins, CD11b and CD11c, that leads to a proinflammatory pattern of macrophage acti...

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Bibliographic Details
Published in:Immunology today (Amsterdam. Regular ed.) 1996-09, Vol.17 (9), p.418-420
Main Authors: Bonnefoy, Jean-Yves, Plater-Zyberk, Christine, Lecoanet-Henchoz, Sybille, Gauchat, Jean-Francois, Aubry, Jean-Pierre, Graber, Pierre
Format: Article
Language:English
Subjects:
Amino Acids - analysis
Animals
Antibodies, Monoclonal - immunology
Arthritis - immunology
Arthritis - pathology
Binding, Competitive - immunology
Humans
Inflammation - immunology
Integrin alphaXbeta2 - metabolism
Macrophage Activation - immunology
Macrophage-1 Antigen - metabolism
Macrophages - immunology
Macrophages - metabolism
Mice
Protein Binding - physiology
Receptors, IgE - biosynthesis
Receptors, IgE - immunology
Receptors, IgE - metabolism
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Summary:CD23, is expressed on a variety of haematopoietic cell types and displays pleiotropic activities in vitro. Here Jean-Yves Bonnefoy and collegues discuss a novel interaction between CD23 and the α chains of the β 2 integrins, CD11b and CD11c, that leads to a proinflammatory pattern of macrophage activation. They describe how neutralizing antibodies to CD23 can decrease the severity of murine arthritis.
ISSN:0167-5699
DOI:10.1016/0167-5699(96)10054-2