Characteristic Upregulation of Dopamine D1-Receptor in Rat Striatum after 6-Hydroxydopamine Treatment

We measured the number of D1-receptors (Bmax) in the striatum whose dopaminergic terminals were destroyed to various degrees by 6-hydroxydopamine (6-OHDA) to clarify the relationship between the degree of denervation and the change in Bmax for D1-receptor. Rats were sacrificed 28 days after 6-OHDA t...

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Bibliographic Details
Published in:Japanese journal of pharmacology 1996, Vol.71(3), pp.255-258
Main Authors: Iwata, Shin-ichi, Shimizu, Takao, Nomoto, Masahiro, Fukuda, Takeo
Format: Article
Language:English
Subjects:
6-Hydroxydopamine
[3H]SCH23390
Animals
Benzazepines - metabolism
Corpus Striatum - chemistry
Corpus Striatum - drug effects
Male
Oxidopamine - pharmacology
Rats
Rats, Wistar
Receptors, Dopamine D1 - analysis
Receptors, Dopamine D1 - drug effects
Receptors, Dopamine D2 - analysis
Receptors, Dopamine D2 - drug effects
Spiperone - metabolism
Up-Regulation
Upregulation
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Summary:We measured the number of D1-receptors (Bmax) in the striatum whose dopaminergic terminals were destroyed to various degrees by 6-hydroxydopamine (6-OHDA) to clarify the relationship between the degree of denervation and the change in Bmax for D1-receptor. Rats were sacrificed 28 days after 6-OHDA treatment, and [3H]SCH23390 (R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine) binding capacity and monoamine content were measured in striatal homogenate. Bmax was significantly upregulated when dopamine content was reduced to less than 5% of that in the vehicle-treated striatum. In contrast, it was significantly decreased when dopamine content was 5–25% of that in the vehicle-treated striatum. The D1-receptors showed either upregulation or downregulation depending on the degree of denervation.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.71.255