Evidence for the promoting role of the intra-uterine kinin release in the development of late hypertonic saline-induced abortion

Blood plasma kininogen (K), kininases (KS), kallikrein (KK), prekallikrein (PKK), and PGF2a were estimated in the common circulation of pregnant women during late saline-induced abortion and also in retroplacental blood after foetus delivery. The results provide evidence for intra-uterine kinin rele...

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Bibliographic Details
Published in:Immunopharmacology 1996-06, Vol.33 (1-3), p.133-136
Main Authors: Makevnina, Lyudmilla G., Nikonov, Andrey P., Goncharova, Valentina N., Morozova, Marya S., Paskhina, Tatyana S.
Format: Article
Language:English
Subjects:
Abortion
Abortion, Induced - methods
Dinoprost - blood
Female
Humans
Kallikrein-kinin system
Kallikrein-Kinin System - physiology
Kallikreins - metabolism
Kininogens - blood
Kinins - secretion
Lysine Carboxypeptidase - blood
Peptidyl-Dipeptidase A - blood
Population
Pregnancy
Pregnancy Maintenance - physiology
Pregnancy Trimester, Second
Prekallikrein - metabolism
Saline Solution, Hypertonic - administration & dosage
Uterine kinin release
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Summary:Blood plasma kininogen (K), kininases (KS), kallikrein (KK), prekallikrein (PKK), and PGF2a were estimated in the common circulation of pregnant women during late saline-induced abortion and also in retroplacental blood after foetus delivery. The results provide evidence for intra-uterine kinin release from circulating blood K by locally activated KK from the very beginning of abortion. The greatest kinin release coincided with the strongest KS activity decrease at the time of foetus delivery. The pre-abortive KS levels correlated directly with abortus duration. Uterine PG biosynthesis was activated, but appeared to be a secondary process.
ISSN:0162-3109
DOI:10.1016/0162-3109(96)00023-9