β-Adrenergic modulation of male sexual behavior elicited from the medial preoptic area in rats

This study was aimed at investigating the role of the adrenergic mechanism in the medial preoptic area (mPOA) in sexual arousal and copulatory performance. Saline, norepinephrine (NE), phenoxybenzamine (PBZ) and propranolol (PROP) were injected into the mPOA in different groups of rats. NE applicati...

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Bibliographic Details
Published in:Behavioural brain research 1996, Vol.74 (1), p.181-187
Main Authors: Mallick, Hrudananda, Kumar Manchanda, Surinder, Mohan Kumar, Velayudhan
Format: Article
Language:English
Subjects:
Adrenergic alpha-Agonists - administration & dosage
Adrenergic alpha-Agonists - pharmacology
Adrenergic alpha-Antagonists - administration & dosage
Adrenergic alpha-Antagonists - pharmacology
Adrenergic beta-Antagonists - administration & dosage
Adrenergic beta-Antagonists - pharmacology
Animals
Arousal - physiology
Behavioral psychophysiology
Biological and medical sciences
Copulation - physiology
Dose-Response Relationship, Drug
Fundamental and applied biological sciences. Psychology
Male
Medial preoptic area
Microinjections
Neurotransmission and behavior
Norepinephrine
Norepinephrine - administration & dosage
Norepinephrine - antagonists & inhibitors
Norepinephrine - pharmacology
Phenoxybenzamine
Phenoxybenzamine - administration & dosage
Phenoxybenzamine - pharmacology
Preoptic Area - physiology
Propranolol
Propranolol - administration & dosage
Propranolol - pharmacology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
Rats, Wistar
Receptors, Adrenergic, beta - drug effects
Receptors, Adrenergic, beta - physiology
Sexual arousal
Sexual behavior
Sexual Behavior, Animal - physiology
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Summary:This study was aimed at investigating the role of the adrenergic mechanism in the medial preoptic area (mPOA) in sexual arousal and copulatory performance. Saline, norepinephrine (NE), phenoxybenzamine (PBZ) and propranolol (PROP) were injected into the mPOA in different groups of rats. NE application (3 μg) facilitated the male sexual behavior by increasing sexual arousal and copulatory performance. On the other hand, application of PROP and PBZ produced inhibition of male sexual behavior. Effects produced by low doses of PROP were more significant than PBZ. The results, viewed in the light of other available reports, suggest that the mPOA β-adrenergic mechanism is important in the elaboration of male sexual behavior.
ISSN:0166-4328
1872-7549
DOI:10.1016/0166-4328(95)00168-9