Localized Amyloid in the Menisci of the Knee Joint

This is, to the best ofour knowledge, the first report on amyloid deposits in menisci. Fragments of menisci gained by arthroscopy from 316 patients between 20 and 80 years of age were examined. Amyloid was found in 70% ofthe cases from male, as well as female patients. The amyloid amount found was a...

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Bibliographic Details
Published in:Pathology, research and practice research and practice, 1996, Vol.192 (6), p.547-551
Main Authors: Rumpelt, H.J., Braun, A., Spier, R., Suren, E.G., Thies, E.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Amyloid
Amyloid - analysis
Amyloid typing
Cartilage - immunology
Cartilage - pathology
Cartilage - surgery
Cartilage - ultrastructure
Female
Humans
Immunohistochemistry
Knee joint
Knee Joint - immunology
Knee Joint - pathology
Knee Joint - surgery
Knee Joint - ultrastructure
Male
Menisci
Menisci, Tibial - immunology
Menisci, Tibial - surgery
Middle Aged
Senile amyloid
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Summary:This is, to the best ofour knowledge, the first report on amyloid deposits in menisci. Fragments of menisci gained by arthroscopy from 316 patients between 20 and 80 years of age were examined. Amyloid was found in 70% ofthe cases from male, as well as female patients. The amyloid amount found was always very small, but the deposits seemed to increase with age. Patients more than 50 years of age all had menisceal amyloid. Two types of deposits were observed: a) stroma-deposits in the deep central portions of the menisci (tiny dots ofintensely stained amyloid and/or ill defined patches of low staining intensity) and b) surface associated deposits: band-like amyloid imbibition ofthe collagenous stroma immediately beneath the surface ofthe menisci but not deeper than 0,2 mm. In all cases, amyloid was resistant when pretreated by KMn04 and immunohistologically antisera against amyloid types AA, AB and AF were negative. 3/25 cases showed a reaction with an amyloid-lambda-antibody. We assume, that amyloid in menisci is a further type of localized senile amyloidosis.
ISSN:0344-0338
1618-0631
DOI:10.1016/S0344-0338(96)80104-X