Liver and intestinal fatty acid binding proteins in control and TGF beta 1 gene targeted deficient mice

The effect of transforming growth factor beta-1 (TGFbeta1) expression on fatty acid binding proteins was examined in control and two strains of gene targeted TGFbeta1-deficient mice. Homozygous TGFbeta1-deficient 129 X CF- 1, expressing multifocal inflammatory syndrome, had 25% less liver fatty acid...

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Bibliographic Details
Published in:Molecular and cellular biochemistry 1996-06, Vol.159 (2), p.149-153
Main Authors: Fontaine, R.N, Gossett, R.E, Schroeder, F, O'Toole, B.A, Doetschman, T, Kier, A.B
Format: Article
Language:English
Subjects:
Animals
binding proteins
Carrier Proteins - biosynthesis
Fatty Acid-Binding Protein 7
Fatty Acid-Binding Proteins
fatty acids
Fatty Acids - metabolism
Gene Deletion
gene expression
Gene Targeting
genes
Inflammation - metabolism
Intestinal Mucosa - metabolism
intestines
liver
Liver - metabolism
Mice
Mice, Inbred C3H
Mice, SCID
Myelin P2 Protein - biosynthesis
Neoplasm Proteins
Nerve Tissue Proteins
Severe Combined Immunodeficiency - metabolism
site-directed mutagenesis
Syndrome
Transforming Growth Factor beta - genetics
Transforming Growth Factor beta - physiology
transforming growth factor deficient mice
transforming growth factors
tumor necrosis factors
Wasting Syndrome - metabolism
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Summary:The effect of transforming growth factor beta-1 (TGFbeta1) expression on fatty acid binding proteins was examined in control and two strains of gene targeted TGFbeta1-deficient mice. Homozygous TGFbeta1-deficient 129 X CF- 1, expressing multifocal inflammatory syndrome, had 25% less liver fatty acid binding protein (L-FABP) when compared to control mice. The decrease in L-FABP expression was not due to multifocal inflammatory syndrome since homozygous TGFbeta1-deficient/immunodeficient C3H mice on a SCID background had 36% lower liver L-FABP than controls. This effect was developmentally related and specific to liver, but not the proximal intestine, where L-FABP is also expressed. Finally, the proximal intestine also expresses intestinal-FABP (I-FABP) which decreased 3-fold in the TGFbeta1-deficient/immunodeficient C3H mice only. Thus, TGFbeta1 appears to regulate the expression of L-FABP and I-FABP in the liver and the proximal intestine, respectively.
ISSN:0300-8177
1573-4919
DOI:10.1007/BF00420917