Use of clozapine in tardive dystonia

1. 1. This open clinical trial (N = 7) measured the course of severe tardive dystonia in chronic psychiatric patients after discontinuation of neuroleptics and subsequent use of clozapine. 2. 2. The dystonia was regularly assessed using the Fahn-Marsden Rating Scale. The eventual concomitant tardive...

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Bibliographic Details
Published in:Progress in neuro-psychopharmacology & biological psychiatry 1996-02, Vol.20 (2), p.263-274
Main Authors: Van Harten, Peter N., Kamphuis, Daan J., Matroos, Glenn E.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Clozapine
Clozapine - therapeutic use
Drug toxicity and drugs side effects treatment
Dystonia - drug therapy
Female
Humans
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Piperidines
tardive dystonia
Toxicity: nervous system and muscle
treatment
Triazoles
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Summary:1. 1. This open clinical trial (N = 7) measured the course of severe tardive dystonia in chronic psychiatric patients after discontinuation of neuroleptics and subsequent use of clozapine. 2. 2. The dystonia was regularly assessed using the Fahn-Marsden Rating Scale. The eventual concomitant tardive dyskinesia was assessed using the Abnormal Involuntary Movement Scale. The mean follow up was 103 weeks. 3. 3. The results for the tardive dystonia: four patients recovered totally, two unproved considerably and one did not recover. 4. 4. The results for the concomitant tardive dyskinesia: five of the seven patients had also dyskinesia, one patient had a total, two a partly remission, one had a very fluctuating course, and one patient worsened. Another patient developed dyskinesia. 5. 5. It is suggested to consider clozapine for patients with tardive dystonia who have to continue antipsychotic treatment.
ISSN:0278-5846
1878-4216
DOI:10.1016/0278-5846(95)00309-6