Herpes simplex: Evolving concepts

A large body of molecular biologic research has begun to clarify some basic aspects of viral latency and reactivation. The clinical definition of herpes simplex virus infection is expanding, with the recognition that the disease is largely asymptomatic and that most transmission occurs during period...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 1996-10, Vol.35 (4), p.503-520
Main Author: Pereira, Frederick A
Format: Article
Language:English
Subjects:
Antibodies, Viral - blood
Antiviral Agents - therapeutic use
Biological and medical sciences
Herpes Simplex - diagnosis
Herpes Simplex - drug therapy
Herpes Simplex - physiopathology
Herpes Simplex - transmission
Human viral diseases
Humans
Infectious diseases
Medical sciences
Simplexvirus - genetics
Simplexvirus - growth & development
Simplexvirus - physiology
Simplexvirus - ultrastructure
Viral diseases
Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye
Virus Activation
Virus Latency
Virus Shedding
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Summary:A large body of molecular biologic research has begun to clarify some basic aspects of viral latency and reactivation. The clinical definition of herpes simplex virus infection is expanding, with the recognition that the disease is largely asymptomatic and that most transmission occurs during periods of asymptomatic viral shedding. With this awareness, serologic diagnosis has become increasingly important. New treatment modalities are now available, and other promising treatments are in development.
ISSN:0190-9622
1097-6787
DOI:10.1016/S0190-9622(96)90670-2