BMY-28438 (3, 7-DIHYDROXYTROPOLONE), A NEW ANTITUMOR ANTIBIOTIC ACTIVE AGAINST B16 MELANOMA: I. PRODUCTION, ISOLATION, STRUCTURE AND BIOLOGICAL ACTIVITY

A new antitumor antibiotic BMY-28438 was isolated from the cultured broth of Streptomyces tropolofadens No. K611-97. The antibiotic showed potent cytotoxicity against cultured B16 melanoma cells and remarkable prolongation of life span of mice bearing B16 melanoma. The structure of BMY-28438 was det...

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Published in:Journal of antibiotics 1988/07/25, Vol.41(7), pp.862-868
Main Authors: SUGAWARA, KOKO, OHBAYASHI, MASARU, SHIMIZU, KEIKO, HATORI, MASAMI, KAMEI, HIDEO, KONISHI, MASATAKA, OKI, TOSHIKAZU, KAWAGUCHI, HIROSHI
Format: Article
Language:English
Subjects:
Animals
Antibiotics, Antineoplastic - biosynthesis
Antibiotics, Antineoplastic - isolation & purification
Antibiotics, Antineoplastic - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral drugs
Bacteria - drug effects
Biological and medical sciences
Biotechnology
Chemical Phenomena
Chemistry
Fermentation
Fundamental and applied biological sciences. Psychology
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
Male
Medical sciences
Mice
Miscellaneous. Antibiotics with multiple activities
Neoplasms, Experimental - drug therapy
Pharmacology. Drug treatments
Production of active biomolecules
Streptomyces - metabolism
Tropolone - analogs & derivatives
Tropolone - isolation & purification
Tropolone - pharmacology
Tumor Cells, Cultured - drug effects
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Summary:A new antitumor antibiotic BMY-28438 was isolated from the cultured broth of Streptomyces tropolofadens No. K611-97. The antibiotic showed potent cytotoxicity against cultured B16 melanoma cells and remarkable prolongation of life span of mice bearing B16 melanoma. The structure of BMY-28438 was determined as 3, 7-dihydroxytropolone on the basis of spectral analyses and direct comparison with the authentic compound synthesized.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.41.862