NOVEL CHOLECYSTOKININ ANTAGONISTS FROM ASPERGILLUS ALLIACEUS: I. FERMENTATION, ISOLATION, AND BIOLOGICAL PROPERTIES

The discovery and biological properties of four novel cholecystokinin antagonists produced by Aspergillus alliaceus is described. One of these was seven times more potent than the previously reported asperlicin.

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Bibliographic Details
Published in:Journal of antibiotics 1988/07/25, Vol.41(7), pp.875-877
Main Authors: GOETZ, M. A., MONAGHAN, R. L., CHANG, R. S. L., ONDEYKA, J., CHEN, T. B., LOTTI, V. J.
Format: Article
Language:English
Subjects:
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Aspergillus - metabolism
Aspergillus alliaceus
Benzodiazepinones - biosynthesis
Benzodiazepinones - isolation & purification
Benzodiazepinones - pharmacology
Biological and medical sciences
Biotechnology
Cholecystokinin - antagonists & inhibitors
Fermentation
Fundamental and applied biological sciences. Psychology
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
Medical sciences
Miscellaneous. Antibiotics with multiple activities
Other active biomolecules
Pharmacology. Drug treatments
Production of active biomolecules
Rats
Citations: Items that cite this one
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Description
Summary:The discovery and biological properties of four novel cholecystokinin antagonists produced by Aspergillus alliaceus is described. One of these was seven times more potent than the previously reported asperlicin.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.41.875