Studies on in vivo and in vitro release of intact parathyroid hormone using a new two‐site immunochemiluminometric assay

Basal parathyroid hormone (PTH) levels measured by a chemiluminescent immunoassay for intact PTH showed good discrimination between normal, n=82 (1.2–9.4 pmol/l), and hyperparathyroid subjects, n=55 (9–200 pmol/l). In malignant hypercalcemia, all PTH levels were within the normal range or suppressed...

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Bibliographic Details
Published in:World journal of surgery 1988-08, Vol.12 (4), p.454-461
Main Authors: Aston, J. Paul, Wheeler, Malcolm H., Brown, Richard C., Curley, Ian R., Woodhead, J. Stuart
Format: Article
Language:English
Subjects:
Adenoma
Adenoma - metabolism
Adult
Aged
Calcitonin
Calcium - metabolism
Extracellular Calcium
Female
Fluorescent Antibody Technique
Humans
Hypercalcemia - blood
Hyperparathyroidism - blood
Hyperplasia - blood
In Vitro Techniques
Kidney Failure, Chronic - blood
Luminescent Measurements
Male
Middle Aged
Parathyroid Adenoma
Parathyroid Glands - metabolism
Parathyroid Glands - pathology
Parathyroid Hormone - metabolism
Parathyroid Neoplasms - metabolism
Salmon Calcitonin
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Summary:Basal parathyroid hormone (PTH) levels measured by a chemiluminescent immunoassay for intact PTH showed good discrimination between normal, n=82 (1.2–9.4 pmol/l), and hyperparathyroid subjects, n=55 (9–200 pmol/l). In malignant hypercalcemia, all PTH levels were within the normal range or suppressed (0.8–5.2 pmol/l). Dynamic studies of PTH release in response to intramuscular salmon calcitonin (100 u) showed no significant rise out of the normal range in controls, but adenoma patients demonstrated a mean rise at 120, 180, and 240 minutes of 22%, 22%, and 35%, respectively, and hyperplasia patients a mean rise of 44%, 63%, and 46%, respectively. The mean absolute rise in PTH concentration was 10.6±7.2 pmol/g parathyroid adenoma and 26.6±19.2 pmol/g hyperplastic parathyroid tissue; this difference being significant (p
ISSN:0364-2313
1432-2323
DOI:10.1007/BF01655419